ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the relationship between bacterial biofilm (BBF) and chronic rhinosinusitis (CRS).</p><p><b>METHODS</b>The database on line was searched to collect the studies on BBF and CRS. The method of meta analysis was used to analyze the data of suitable studies.</p><p><b>RESULTS</b>Fourteen studies were included. System evaluation indicated that the BBF detection rate in CRS group was significantly higher than that in the control group (OR = 17.01, P < 0.01), and the nasal surgery's rate of BBF positive group was significantly higher than the negative group (OR = 3.99, P < 0.01). Preoperative Lund-Kennedy endoscopic score, Lund-MacKay CT score, symptom severity score, postoperative Lund-Kennedy score after six months showed no difference between BBF positive group and negative group.</p><p><b>CONCLUSION</b>The presence of BBF is related to the pathogenesis of CRS and the history of nasal surgery.</p>